35 ED patients aged 18 to 82 (mean = 36.5; standard deviation (SD) = 15.4) with a chief complaint of anxiety or panic attack symptoms were included. Patients with additional chief complaints, or with past medical history of obstructive respiratory disease, bipolar disorder, suicidality, and/or substance use were excluded. The mean PSS score was significantly lower (mean difference (MD) 15.6, 95% confidence interval (CI) 12.2 to 19.1, p<0.01) after use of the CalmiGo device. The mean change in PSS scores after device use was significantly greater (MD 10.7, 95% CI 4.8 to 16.6, p<0.01) in the severe anxiety group, compared to the minimal, mild, and moderate anxiety group. There was no significant difference between the patients who took anxiety medications and those who did not for the mean PSS change (MD 3.1, 95% CI -3.8 to 10.0, p=0.36) nor for the mean GAD-7 score (MD 3.2, 95% CI -0.9 to 7.2, p=0.12).